BindingDB logo
myBDB logout

BDBM50219675 4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-5-methylthiazol-2-yl)benzamide::CHEMBL248389

InChI string: InChI=1S/C24H20F4N6OS/c1-13-21(15-6-9-18(25)17(10-15)24(26,27)28)32-23(36-13)33-22(35)14-4-7-16(8-5-14)31-19-11-20(34(2)3)30-12-29-19/h4-12H,1-3H3,(H,29,30,31)(H,32,33,35)

SMILES: CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(C)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1

InChI Key: InChIKey=LNFOWBSRYNOJJG-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50219675   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219675
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(C)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H20F4N6OS/c1-13-21(15-6-9-18(25)17(10-15)24(26,27)28)32-23(36-13)33-22(35)14-4-7-16(8-5-14)31-19-11-20(34(2)3)30-12-29-19/h4-12H,1-3H3,(H,29,30,31)(H,32,33,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 45n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Bioorg Med Chem Lett 17: 5447-54 (2007)

More data for this
Ligand-Target Pair