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BDBM50219679 CHEMBL247645::N-(4-(2,4-difluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-4-(pyrimidin-4-ylamino)benzamide

InChI string: InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)

SMILES: Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F

InChI Key: InChIKey=SYIXSYVLTFSTAU-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50219679   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair