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BDBM50219715 CHEMBL245794::N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-4-(6-methylpyrimidin-4-ylamino)benzamide

InChI string: InChI=1S/C22H15F4N5OS/c1-12-9-18(28-11-27-12)29-14-7-5-13(6-8-14)20(32)31-21-30-17(10-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)

SMILES: Cc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1

InChI Key: InChIKey=QVHFGIIUSKUDFI-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50219715   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219715
PNG
(CHEMBL245794 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Cc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H15F4N5OS/c1-12-9-18(28-11-27-12)29-14-7-5-13(6-8-14)20(32)31-21-30-17(10-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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PC sid
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Similars

AffyNet 
Article
PubMed
n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair