BDBM50220303 1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiperidin-2-yl)cyclopropyl 4-(2-hydroxyethyl)piperazine-1-carboxylate::CHEMBL240070

SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCN(CCO)CC1

InChI Key InChIKey=DJWUDIFTUQYCIR-TZIWHRDSSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50220303   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220303(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220303(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed