BDBM50221346 4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-methoxy-naphthalen-2-yl)-1-methyl-3H-imidazol-4-yl]-pyridine::CHEMBL237570

SMILES COc1ccc2cc(ccc2c1)-c1c(nc(-c2ccc(cc2C)S(C)=O)n1C)-c1ccncc1

InChI Key InChIKey=BARYYLFEOIUPEY-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50221346   

TargetInsulin receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of IGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50:  550nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PKCbeta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50221346(4-[2-(4-methanesulfinyl-2-methyl-phenyl)-5-(6-meth...)
Affinity DataIC50:  296nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed