BDBM50221516 6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phenylcyclopropylamino)quinoline-3-carbonitrile::CHEMBL248392

SMILES COc1cc2c(N[C@@H]3C[C@H]3c3ccccc3)c(cnc2cc1OCCCN1CCOCC1)C#N

InChI Key InChIKey=NHWFEYYJOLZGNB-XUZZJYLKSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50221516   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataKi:  8.40nMAssay Description:Inhibition of human recombinant EGFR by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataKi:  45nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataKi:  200nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataKi:  350nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataKi:  420nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Tanabe Research Laboratories Usa

Curated by ChEMBL
LigandPNGBDBM50221516(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human EGFR autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed