BDBM50222222 CHEMBL394956::KYS-05090::N-benzyl-2-(3-(biphenyl-4-yl)-2-((5-(dimethylamino)pentyl)(methyl)amino)-3,4-dihydroquinazolin-4-yl)acetamide::N-benzyl-2-{3-biphenyl-4-yl-2-[(5-dimethylamino-pentyl)-methyl-amino]-3,4-dihydro-quinazolin-4-yl}-acetamide

SMILES CN(C)CCCCCN(C)C1=Nc2ccccc2C(CC(=O)NCc2ccccc2)N1c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=QVXCZTNUVKNCGU-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50222222   

TargetCholinesterase(Equus caballus (Horse))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataKi:  51nMAssay Description:Mixed/noncompetitive inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human T-type calcium channel alpha1G in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of T-type calcium channel Cav3.1 alpha1G subunit expressed in HEK293 cells assessed as calcium current by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of T-type calcium channel Cav3.1 alpha1G expressed in HEK293 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of T-type calcium channel alpha 1 GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of N-type calcium channel alpha 1 BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  510nMAssay Description:Inhibition of T type calcium channel Cav3.1 (unknown origin) expressed in HEK293T cells by patch clamp method relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced curr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human Cav3.2 expressed in tsA-201 cells by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human Cav3.1 expressed in tsA-201 cells by patch clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of T-type CaV3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium current by whole cell patch-clamp me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50222222(CHEMBL394956 | KYS-05090 | N-benzyl-2-(3-(biphenyl...)
Affinity DataIC50:  62nMAssay Description:Inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed