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BDBM50222256 (E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-hydroxyphenyl)piperidin-1-yl)methyl)piperidin-1-yl)prop-2-en-1-one::CHEMBL248813

SMILES: Oc1ccc(cc1)C1CCN(CC2CCN(CC2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1

InChI Key: InChIKey=OXTXXOYXEVCBGN-KRXBUXKQSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50222256   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM50222256
PNG
((E)-3-(3,4-dichlorophenyl)-1-(4-((4-(4-hydroxyphen...)
Show SMILES Oc1ccc(cc1)C1CCN(CC2CCN(CC2)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C26H30Cl2N2O2/c27-24-7-1-19(17-25(24)28)2-8-26(32)30-15-9-20(10-16-30)18-29-13-11-22(12-14-29)21-3-5-23(31)6-4-21/h1-8,17,20,22,31H,9-16,18H2/b8-2+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 510n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125]MCP1 from human CCR2 receptor in THP1 cells


Bioorg Med Chem Lett 17: 5964-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.065
BindingDB Entry DOI: 10.7270/Q2WD408X
More data for this
Ligand-Target Pair