BDBM50222303 4',6,7,-trihydroxyisoflavone::4',6,7-trihydroxyisoflavone::6,7,3'-trihydroxyisoflavone::6,7,4'-trihydroxyisoflavone::6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one::CHEMBL239156::IR-1

SMILES Oc1ccc(cc1)-c1coc2cc(O)c(O)cc2c1=O

InChI Key InChIKey=GYLUFQJZYAJQDI-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50222303   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago

LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50: >1.00E+5nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidad De Santiago

LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50: >4.00E+4nMpH: 7.3 T: 2°CAssay Description:The reactions were done in a volume of 2 mL and constantly stirred using a magnetic stir bar at room temperature (23 °C). Reactions with the crude, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago

LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50:  1.62E+5nMAssay Description:Inhibition of human DNA topoisomerase 2 catalytic domain-mediated knotted bacteriophage P4Virl dell0 DNA unknotting by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xanthine oxidase (unknown origin) assessed as decrease of superoxide generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of xanthine oxidase (unknown origin) assessed as decrease of uric acid generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Mus musculus (Mouse))
Amorepacific

Curated by ChEMBL
LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of tyrosinase in mouse Melan-a cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM50222303(4',6,7,-trihydroxyisoflavone | 4',6,7-trihydroxyis...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed