BDBM50224182 (R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazin-1-yl)-3-(4-chlorophenyl)-2-methylpropan-1-one::1-{2-[(1S)-amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine::CHEMBL401250

SMILES CC(C)[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1

InChI Key InChIKey=IMYWIXVEAKDSQK-DVECYGJZSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50224182   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataKi:  69nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataKi:  69nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataIC50:  2.40E+3nMAssay Description:Antagonist activity at human MC4R expressed in CHO cells assessed as inhibition of alpha-MSH-induced cAMP production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataIC50:  2.40E+3nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed