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BDBM50224478 (1S,5S)-3-(5,6-dibromopyridin-3-yl)-3,6-diazabicyclo[3.2.0]-heptane::CHEMBL393247

SMILES: Brc1cc(cnc1Br)N1C[C@@H]2CN[C@@H]2C1

InChI Key: InChIKey=GVVFNYMGPONAFJ-IMTBSYHQSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224478   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50224478
PNG
((1S,5S)-3-(5,6-dibromopyridin-3-yl)-3,6-diazabicyc...)
Show SMILES Brc1cc(cnc1Br)N1C[C@@H]2CN[C@@H]2C1
Show InChI InChI=1S/C10H11Br2N3/c11-8-1-7(3-14-10(8)12)15-4-6-2-13-9(6)5-15/h1,3,6,9,13H,2,4-5H2/t6-,9+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.20E+3n/an/an/an/a



Neuroscience Research

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human alpha-4-beta-2 nAChR expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay


J Med Chem 50: 5493-508 (2007)


Article DOI: 10.1021/jm070755h
BindingDB Entry DOI: 10.7270/Q2F190ZZ
More data for this
Ligand-Target Pair