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BDBM50224484 (1S,5R)-6-(5-bromopyridin-3-yl)-3,6-diazabicyclo[3.2.0]-heptane::CHEMBL239714

SMILES: Brc1cncc(c1)N1C[C@@H]2CNC[C@H]12

InChI Key: InChIKey=OGULMRQWNAMFPB-XVKPBYJWSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50224484   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Homo sapiens (Human))
BDBM50224484
PNG
((1S,5R)-6-(5-bromopyridin-3-yl)-3,6-diazabicyclo[3...)
Show SMILES Brc1cncc(c1)N1C[C@@H]2CNC[C@H]12
Show InChI InChI=1S/C10H12BrN3/c11-8-1-9(4-13-3-8)14-6-7-2-12-5-10(7)14/h1,3-4,7,10,12H,2,5-6H2/t7-,10-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.14E+4n/an/an/an/a



Neuroscience Research

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human alpha-4-beta-2 nAChR expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay


J Med Chem 50: 5493-508 (2007)


Article DOI: 10.1021/jm070755h
BindingDB Entry DOI: 10.7270/Q2F190ZZ
More data for this
Ligand-Target Pair