BDBM50225081 1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-hydroxy-3-(piperazin-1-yl)propyl)piperazin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one::CHEMBL401418

SMILES Cc1cc(C)cc(c1)-c1[nH]c2sc(cc2c1CCN1CCN(CC(O)CN2CCNCC2)CC1)C(C)(C)C(=O)N1C2CCC1CC2

InChI Key InChIKey=AGZBTOKWUUPEBM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50225081   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225081(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50:  171nMAssay Description:Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pitutary cells assessed as inhibition of GnRH stimulated LH release after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225081(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50:  74nMAssay Description:Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225081(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50225081(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dime...)
Affinity DataIC50:  55nMAssay Description:Displacement of [125I]D-Trp from rat GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed