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BDBM50225275 CHEMBL238659::H-imidazo[2,1-a]isoquinoline-2-carbohydrazide::IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE

SMILES: NNC(=O)c1cn2ccc3ccccc3c2n1

InChI Key: InChIKey=WSNWYZBDIKCPIG-UHFFFAOYSA-N

Data: 6 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50225275   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50225275
PNG
(CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...)
Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1
Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
DrugBank
MMDB
PDB
Article
PubMed
n/an/a 4.31E+3n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 100 uM Manganese


J Med Chem 50: 5735-42 (2007)


Article DOI: 10.1021/jm700930k
BindingDB Entry DOI: 10.7270/Q2JQ10R2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50225275
PNG
(CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...)
Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1
Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
DrugBank
MMDB
PDB
Article
PubMed
n/an/a 1.74E+4n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 6 uM Iron


J Med Chem 50: 5735-42 (2007)


Article DOI: 10.1021/jm700930k
BindingDB Entry DOI: 10.7270/Q2JQ10R2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50225275
PNG
(CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...)
Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1
Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
DrugBank
MMDB
PDB
Article
PubMed
n/an/a 640n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 5 uM Manganese


J Med Chem 50: 5735-42 (2007)


Article DOI: 10.1021/jm700930k
BindingDB Entry DOI: 10.7270/Q2JQ10R2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50225275
PNG
(CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...)
Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1
Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
DrugBank
MMDB
PDB
Article
PubMed
n/an/a 2.44E+3n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 1 uM Cobalt


J Med Chem 50: 5735-42 (2007)


Article DOI: 10.1021/jm700930k
BindingDB Entry DOI: 10.7270/Q2JQ10R2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50225275
PNG
(CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...)
Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1
Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
DrugBank
MMDB
PDB
Article
PubMed
n/an/a 2.78E+4n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 100 uM Cobalt


J Med Chem 50: 5735-42 (2007)


Article DOI: 10.1021/jm700930k
BindingDB Entry DOI: 10.7270/Q2JQ10R2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50225275
PNG
(CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carb...)
Show SMILES NNC(=O)c1cn2ccc3ccccc3c2n1
Show InChI InChI=1S/C12H10N4O/c13-15-12(17)10-7-16-6-5-8-3-1-2-4-9(8)11(16)14-10/h1-7H,13H2,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
DrugBank
MMDB
PDB
Article
PubMed
n/an/a 6.15E+3n/an/an/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli methionine aminopeptidase in presence of 10 uM Nickel


J Med Chem 50: 5735-42 (2007)


Article DOI: 10.1021/jm700930k
BindingDB Entry DOI: 10.7270/Q2JQ10R2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)