BDBM50225508 CHEBI:31401::Cilostazol::OPC-13013::OPC-21::Pletal

SMILES O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1

InChI Key InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50225508   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50:  190nMAssay Description:Inhibition of low Km cAMP phosphodiesterase PDE III of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Shiraz University

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human PDE3A expressed in Sf9 cells using cAMP as substrate after 3 hrs by IMAP TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50:  9.12E+4nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human platelet PDE3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225508(CHEBI:31401 | Cilostazol | OPC-13013 | OPC-21 | Pl...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed