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BDBM50226326 CHEMBL31957

SMILES: CC(C)Nc1nc(nc(Cl)c1C)N1CCN(C)CC1

InChI Key: InChIKey=GXXYWRIQRRWSNG-UHFFFAOYSA-N

Data: 3 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50226326   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226326
PNG
(CHEMBL31957)
Show SMILES CC(C)Nc1nc(nc(Cl)c1C)N1CCN(C)CC1
Show InChI InChI=1S/C13H22ClN5/c1-9(2)15-12-10(3)11(14)16-13(17-12)19-7-5-18(4)6-8-19/h9H,5-8H2,1-4H3,(H,15,16,17)
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
16n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes


J Med Chem 29: 1394-8 (1986)


Article DOI: 10.1021/jm00158a013
BindingDB Entry DOI: 10.7270/Q21R6SQQ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50226326
PNG
(CHEMBL31957)
Show SMILES CC(C)Nc1nc(nc(Cl)c1C)N1CCN(C)CC1
Show InChI InChI=1S/C13H22ClN5/c1-9(2)15-12-10(3)11(14)16-13(17-12)19-7-5-18(4)6-8-19/h9H,5-8H2,1-4H3,(H,15,16,17)
Reactome pathway
KEGG

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity was measured as the inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat cortical membranes


J Med Chem 29: 1394-8 (1986)


Article DOI: 10.1021/jm00158a013
BindingDB Entry DOI: 10.7270/Q21R6SQQ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50226326
PNG
(CHEMBL31957)
Show SMILES CC(C)Nc1nc(nc(Cl)c1C)N1CCN(C)CC1
Show InChI InChI=1S/C13H22ClN5/c1-9(2)15-12-10(3)11(14)16-13(17-12)19-7-5-18(4)6-8-19/h9H,5-8H2,1-4H3,(H,15,16,17)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
880n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity to Dopamine receptors of rat striatal membranes by [3H]spiroperidol displacement.


J Med Chem 29: 1394-8 (1986)


Article DOI: 10.1021/jm00158a013
BindingDB Entry DOI: 10.7270/Q21R6SQQ
More data for this
Ligand-Target Pair