BDBM50226442 2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydro-3H-pyrimidin-4-one::CHEMBL392662

SMILES COc1cccc(c1)-c1cccc(c1)C1(C)CC(=O)N(C)C(N)=N1

InChI Key InChIKey=LQOCXPOKEPYGTJ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50226442   

TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1 by IGEN assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of human full length BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 by SPR assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  380nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair