BDBM50227159 2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl)benzylamino)-2,3-dimethylphenyl)acetic acid::CHEMBL253521

SMILES Cc1c(C)c(NCc2cccc(c2)-c2c(Cc3ccccc3)cnc3c(cccc23)C(F)(F)F)ccc1CC(O)=O

InChI Key InChIKey=GCAJNTSVNKDATQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50227159   

TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50227159(2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  4nMAssay Description:Binding affinity at human LXRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50227159(2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  5.80E+4nMAssay Description:Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transacti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50227159(2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  58nMAssay Description:Binding affinity at human LXRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50227159(2-(4-(3-(3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)
Affinity DataIC50:  4.00E+3nMAssay Description:Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed