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BDBM50227890 CHEMBL6343

SMILES: COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(NC(=O)CBr)cc1

InChI Key: InChIKey=WIQUTGGWWJYKFM-VMPITWQZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50227890   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50227890
PNG
(CHEMBL6343)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(NC(=O)CBr)cc1
Show InChI InChI=1S/C25H27BrN6O4/c1-35-20-13-18-19(14-21(20)36-2)29-25(30-24(18)27)32-11-9-31(10-12-32)23(34)8-5-16-3-6-17(7-4-16)28-22(33)15-26/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,33)(H2,27,29,30)/b8-5+
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Similars

Article
PubMed
n/an/a 68n/an/an/an/an/an/a



National Institute on Aging/GRC

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentration


J Med Chem 32: 96-100 (1989)


Article DOI: 10.1021/jm00121a020
BindingDB Entry DOI: 10.7270/Q20G3NCC
More data for this
Ligand-Target Pair