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BDBM50228861 CHEMBL169269

SMILES: O=C(NCc1ccccc1)c1cccnc1Oc1cccc(c1)C#N

InChI Key: InChIKey=NADFJKQNWLNBTH-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50228861   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228861
PNG
(CHEMBL169269)
Show SMILES O=C(NCc1ccccc1)c1cccnc1Oc1cccc(c1)C#N
Show InChI InChI=1S/C20H15N3O2/c21-13-16-8-4-9-17(12-16)25-20-18(10-5-11-22-20)19(24)23-14-15-6-2-1-3-7-15/h1-12H,14H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
BindingDB Entry DOI: 10.7270/Q2DB843T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228861
PNG
(CHEMBL169269)
Show SMILES O=C(NCc1ccccc1)c1cccnc1Oc1cccc(c1)C#N
Show InChI InChI=1S/C20H15N3O2/c21-13-16-8-4-9-17(12-16)25-20-18(10-5-11-22-20)19(24)23-14-15-6-2-1-3-7-15/h1-12H,14H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
BindingDB Entry DOI: 10.7270/Q2DB843T
More data for this
Ligand-Target Pair