BDBM50229193 CHEMBL400721::US9096559, 17::methyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate

SMILES COC(=O)NCc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1

InChI Key InChIKey=XPYFYVJCMDDGKF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50229193   

TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50:  6nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50:  105nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229193(CHEMBL400721 | US9096559, 17 | methyl 4-((2-amino-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed