BDBM50229378 (R)-N-(1-(3-(4-cyanophenyl)H-imidazo[1,2-a]pyridin-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)acetamide::CHEMBL398941

SMILES CCS(=O)(=O)CCN([C@H](C)c1nc2ccccn2c1-c1ccc(cc1)C#N)C(=O)Cc1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=CRLTWFPBUDXVON-LJQANCHMSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50229378   

TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229378((R)-N-(1-(3-(4-cyanophenyl)H-imidazo[1,2-a]pyridin...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-IP-10 from CXCR3 receptor expressed in human PBMC in RPMI-1640 buffer supplemented with 0.5% BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229378((R)-N-(1-(3-(4-cyanophenyl)H-imidazo[1,2-a]pyridin...)
Affinity DataIC50:  21nMAssay Description:Displacement of [125I]-IP-10 from CXCR3 receptor expressed in human PBMC in EDTA-anti-coagulated human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229378((R)-N-(1-(3-(4-cyanophenyl)H-imidazo[1,2-a]pyridin...)
Affinity DataIC50:  72nMAssay Description:Antagonist activity at CXCR3 assessed as ITAC-mediated migration of human PBMC in presence of 100% human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed