BDBM50229657 (S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-phenylpiperazin-1-ylsulfonyl)methyl)piperidine-1-carboxylate::CHEMBL399351

SMILES ONC(=O)C1(CS(=O)(=O)N2CCN(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1

InChI Key InChIKey=JGSJEYLQTZAQRG-IBGZPJMESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50229657   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  78nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  774nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  925nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed