BDBM50229787 (4S,5R)-Nutlin-3::(rac)-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl)(piperazin-1-yl)methanone::4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one::4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one::4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one::CHEMBL191334::NUTLIN-3::Nutlin-3a::rac-4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

SMILES: CC(C)Oc1cc(ccc1C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)c4ccc(cc4)Cl)c5ccc(cc5)Cl)OC

InChI Key: InChIKey=BDUHCSBCVGXTJM-UHFFFAOYSA-N

Data: 17 KI  25 IC50  3 Kd

PDB links: 10 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 49 hits for monomerid = 50229787   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Dog)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Mouse)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		121	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein Mdm4 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		6.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Human)	BDBM50229787 (CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair