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BDBM50230982 CHEMBL4097422

SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(C)C(=O)N=C3N)cc2)n1

InChI Key: InChIKey=TUFMSNXPFKCPHN-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50230982   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Atrial natriuretic peptide receptor


(Homo sapiens)
BDBM50230982
PNG
(CHEMBL4097422)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)CC1N(C(N)=NC1=O)c1nc(NC(N)=N)nc(Nc2ccc(Nc3nc(NC(N)=N)nc(n3)N3C(C)C(=O)N=C3N)cc2)n1
Show InChI InChI=1S/C25H32N20O2.2C2HF3O2/c1-9(2)8-13-15(47)35-19(31)45(13)25-41-21(39-23(43-25)37-17(28)29)33-12-6-4-11(5-7-12)32-20-38-22(36-16(26)27)42-24(40-20)44-10(3)14(46)34-18(44)30;2*3-2(4,5)1(6)7/h4-7,9-10,13H,8H2,1-3H3,(H2,30,34,46)(H2,31,35,47)(H5,26,27,32,36,38,40,42)(H5,28,29,33,37,39,41,43);2*(H,6,7)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

PubMed
n/an/an/an/a 19n/an/an/an/a



Asubio Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human NPR-A expressed in CHO cells assessed as increase in cGMP accumulation after 30 mins by radioimmunoassay


Bioorg Med Chem 25: 1762-1769 (2017)

More data for this
Ligand-Target Pair