BDBM50232354 CHEMBL4066920

SMILES CN(C)Cc1cn(c2c1cccc2)Cc3ccc(cc3)C(=O)NO

InChI Key InChIKey=LYCCCRFBRDLGGA-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50232354   

TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 4nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 5nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 21.7nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in Sf9 cells using RHKK(Ac) as substrate after 90 mins by fluorimet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 158nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC6 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 398nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected insect cells measured after 40 mins by HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 631nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full-length C-terminal FLAG-fused/His-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells measured after 40 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 7.13E+3nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 expressed in Sf21 cells using RHKK(Ac) as substrate after 60 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50232354(CHEMBL4066920)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 expressed in insect cells using RHKK(Ac) as substrate after 60 mins by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2019
Entry Details Article
PubMed