BDBM50234094 CHEMBL4089715

SMILES Cl.OC(=O)[C@@H]1C[C@H](CN1)Oc1ccccc1C(O)=O

InChI Key InChIKey=BJTDKEZUWJPODY-JXLXBRSFSA-N

Data  5 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50234094   

TargetGlutamate receptor ionotropic, kainate 1(RAT)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataKi:  2.27E+3nMAssay Description:Displacement of [3H]-(2S,4R)-4-Methylglutamic acid from rat eGFP-fused GluK1 receptor LBD expressed in HEK293T/17 cells by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [3H]NF608 from eGFP-fused recombinant rat full length GluK1 receptor expressed in HEK293T/17 cells by liquid scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataKi:  4.00E+3nMAssay Description:Displacement of [3H]NF608 from eGFP-fused recombinant rat full length GluK1 receptor expressed in HEK293T/17 cells by liquid scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]kainic acid from eGFP-fused recombinant rat full length GluK3 receptor expressed in HEK293T/17 cells by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]kainic acid from eGFP-fused recombinant rat full length GluK2 receptor expressed in HEK293T/17 cells by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at recombinant rat full length GluK2 receptor expressed in HEK293T cells assessed as inhibition of glutamate induced increase in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake after 15 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake after 15 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake after 15 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50234094(CHEMBL4089715)
Affinity DataIC50:  5.70E+3nMAssay Description:Antagonist activity at recombinant rat full length GluK1 receptor expressed in HEK293T cells assessed as inhibition of glutamate induced increase in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed