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BDBM50234185 CHEMBL4072048

SMILES: COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CC(C)N(C)C(C)C1

InChI Key: InChIKey=PRYBDIYFEXNDDP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50234185   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50234185
PNG
(CHEMBL4072048)
Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CC(C)N(C)C(C)C1
Show InChI InChI=1S/C31H35N7O3/c1-7-28(39)33-22-9-8-10-24(14-22)38-29(40)13-19(2)25-16-32-31(35-30(25)38)34-26-12-11-23(15-27(26)41-6)37-17-20(3)36(5)21(4)18-37/h7-16,20-21H,1,17-18H2,2-6H3,(H,33,39)(H,32,34,35)
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Similars

Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 126: 1107-1117 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.006
BindingDB Entry DOI: 10.7270/Q2F47RD5
More data for this
Ligand-Target Pair