BDBM50236254 7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one::CHEMBL401896

SMILES CCO\N=C(/C)c1ccc2n(C(C)C)c3c4CCc5nn(C)cc5-c4c4C(=O)NCc4c3c2c1

InChI Key InChIKey=QGMACHJORMNYMR-FJEPWZHXSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50236254   

TargetInsulin receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236254(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236254(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVEC cells at 50 nM relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236254(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236254(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of c-srcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236254(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50236254(7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(propan-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant TIE2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed