BDBM50236292 4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(dimethylsulfamoyl)butanamide::CHEMBL403313

SMILES CN(C)S(=O)(=O)NC(=O)CCCc1c([nH]c2ccc(cc12)C#N)-c1ccc(F)cc1

InChI Key InChIKey=ANXLTXNOZIKJSV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50236292   

TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human cloned CXCR2 by calcium flux FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50:  50nMAssay Description:Displacement of europium labeled-human IL8 from human cloned CXCR2 expressed in Sf9 membrane with Galphai3-beta-1-gamma-2 by DELFIA binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Oryctolagus cuniculus)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at rabbit CXCR2 by neutrophil chemotaxis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50236292(4-[5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl]-N-(di...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed