BDBM50237425 CHEMBL4101628

SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc3[nH]cnc3c2)c1

InChI Key InChIKey=FARVPJMTWVKGMK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50237425   

TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237425(CHEMBL4101628)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237425(CHEMBL4101628)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237425(CHEMBL4101628)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details Article
PubMed