BDBM50237614 BW-759U::CHEBI:465284::Cymevene::Cytovene::Ganciclovir::RS-21592::Virgan::Vitrasert::Zirgan

SMILES Nc1nc(O)c2ncn(COC(CO)CO)c2n1

InChI Key InChIKey=IRSCQMHQWWYFCW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50237614   

TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237614(BW-759U | CHEBI:465284 | Cymevene | Cytovene | Gan...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237614(BW-759U | CHEBI:465284 | Cymevene | Cytovene | Gan...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
California Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50237614(BW-759U | CHEBI:465284 | Cymevene | Cytovene | Gan...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of p97 (unknown origin) incubated for 15 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237614(BW-759U | CHEBI:465284 | Cymevene | Cytovene | Gan...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237614(BW-759U | CHEBI:465284 | Cymevene | Cytovene | Gan...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50237614(BW-759U | CHEBI:465284 | Cymevene | Cytovene | Gan...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed