BindingDB PrimarySearch

BDBM50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib

SMILES: Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F

InChI Key: InChIKey=HHZIURLSWUIHRB-UHFFFAOYSA-N

Data: 38 KI 69 IC50 457 Kd 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 611 hits for monomerid = 50237710
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>700	n/a	n/a	n/a	n/a	n/a	n/a
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Discoidin domain-containing receptor 2 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Breakpoint cluster region protein [1-693] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [229-512] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [229-512] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 2 [596-900] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	415	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	347	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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Mast/stem cell growth factor receptor Kit (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
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Macrophage colony-stimulating factor 1 receptor (Mouse)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	534	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a
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Broad substrate specificity ATP-binding cassette transporter ABCG2 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosyldihydronicotinamide dehydrogenase [quinone] (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.870	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Breakpoint cluster region protein (Mouse)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Crk-like protein (Mus musculus)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50237710 (AMN 107 \| AMN107 \| 4-methyl-N-[3-(4-methyl-1H-imid...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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