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BDBM50238538 CHEMBL4102895

SMILES: COC(=O)c1ccccc1NC(=O)CSc1nc2c(C)cccc2[nH]1

InChI Key: InChIKey=ZIHSDLLMPWYVGH-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50238538   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRMT5/MEP50 Enzyme


(Homo sapiens (Human))
BDBM50238538
PNG
(CHEMBL4102895)
Show SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2c(C)cccc2[nH]1
Show InChI InChI=1S/C18H17N3O3S/c1-11-6-5-9-14-16(11)21-18(20-14)25-10-15(22)19-13-8-4-3-7-12(13)17(23)24-2/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...


J Med Chem 60: 6289-6304 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00587
BindingDB Entry DOI: 10.7270/Q2D220XW
More data for this
Ligand-Target Pair