BDBM50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149

SMILES Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12

InChI Key InChIKey=FDLFGCPTRMXATH-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50239407   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  13.5nMAssay Description:Inhibition of mouse 11beta HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human 11beta HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of mouse 11beta HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of mouse 11-beta-HSD2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at PXRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  14nMAssay Description:Inhibition of mouse 11-beta-HSD1 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human 11-beta-HSD2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50239407(3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexa...)
Affinity DataIC50:  14nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed