BDBM50240510 CHEMBL898::DIFLUNISAL

SMILES OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F

InChI Key InChIKey=HUPFGZXOMWLGNK-UHFFFAOYSA-N

Data  9 KI  10 IC50  10 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50240510   

TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  75nMAssay Description:Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  407nMAssay Description:Binding affinity to transthyretin (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  580nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetSolute carrier family 22 member 6(Human)
Gilead Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 850nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details
PubMed
TargetAlbumin(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.23E+3nMAssay Description:Binding affinity to human serum albumin by PAMPA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as dissociation constant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as acid mediated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Human)
University of Texas At San Antonio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  2.56E+3nMAssay Description:Competitive inhibition of human ACMSD using ACMS substrate by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  2.70E+3nMAssay Description:Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlbumin(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2019
Entry Details Article
PubMed
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataEC50:  3.25E+3nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetCarbonic anhydrase 1(Human)
Ataturk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 3.38E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 3.50E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  5.60E+3nMAssay Description:Stabilization of TTR V30M mutant (unknown origin) assessed as inhibition of protein-mediated amyloid fibril formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataEC50:  5.60E+3nMAssay Description:Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  8.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ataturk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  8.45E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  9.37E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
St. Bartholomew'S and The Royal London School of Medicine and Dentistry

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2012
Entry Details Article
PubMed
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataEC50:  1.06E+4nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2011
Entry Details
PCBioAssay
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ANS binding to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as BC50 for ANS binding to TTR at 5 uM in presen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Human)
University of Texas At San Antonio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of human ACMSD using ACMS substrate by spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 2.50E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetSolute carrier family 12 member 5(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataEC50:  2.57E+4nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2011
Entry Details
PCBioAssay
TargetDihydrofolate reductase(Human)
University of Tennessee

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  3.40E+4nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetGenome polyprotein(WNV)
University of Pittsburgh

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 5.00E+4nMAssay Description:The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetAlbumin(Human)
Universitat De Barcelona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKi:  5.88E+4nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
University of Svizzera Italiana

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to full-length N-terminal 6His-tagged HMGB1 (unknown origin) by NMR spectraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed