BindingDB logo
myBDB logout

BDBM50240750 ()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine::(+/-)-Pinacidil::4N-cyanoimino(1,2,2-trimethylpropylamino)methyl-4-pyridinamine(Pinacidil)::4N-cyanoimino[1,2,2-trimethyl-(1R)-propylamino]methyl-4-pyridinamine::4N-cyanoimino[1,2,2-trimethyl-(1S)-propylamino]methyl-4-pyridinamine::CHEMBL1159::N''-cyano-N-pyridin-4-yl-N'-(1,2,2-trimethylpropyl)guanidine::N''-cyano-N-pyridin-4-yl-N'-(1,2,2-trimethylpropyl)guanidine ((+)-pinacidil)::N''-cyano-N-pyridin-4-yl-N'-(1,2,2-trimethylpropyl)guanidine (Pinacidil)::N''-cyano-N-pyridin-4-yl-N'-[(1R)-1,2,2-trimethylpropyl]guanidine::N''-cyano-N-pyridin-4-yl-N'-[(1S)-1,2,2-trimethylpropyl]guanidine::N-Pyridin-4-yl-N'-(1,2,2-trimethyl-propyl)-cyanoguanidine (pinacidil)::PINACIDIL

SMILES: CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C

InChI Key: InChIKey=IVVNZDGDKPTYHK-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50240750   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50240750
PNG
(()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylprop...)
Show SMILES CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C
Show InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
320n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


J Med Chem 41: 271-5 (1998)


Article DOI: 10.1021/jm970762d
BindingDB Entry DOI: 10.7270/Q2FN159P
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50240750
PNG
(()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylprop...)
Show SMILES CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C
Show InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 3.54E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Bioorg Med Chem 17: 855-66 (2009)


Article DOI: 10.1016/j.bmc.2008.11.055
BindingDB Entry DOI: 10.7270/Q2N017FM
More data for this
Ligand-Target Pair