BDBM50240826 AZD-1775::MK-1775::US11124518, Example AZD1775::US11248006, Compound AZD1775::US11479555, Example AZD1775::US20240182482, Compound MK-1775

SMILES: CC(C)(c1cccc(n1)N2c3c(cnc(n3)Nc4ccc(cc4)N5CCN(CC5)C)C(=O)N2CC=C)O

InChI Key: InChIKey=BKWJAKQVGHWELA-UHFFFAOYSA-N

Data: 2 KI  24 IC50  8 Kd

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50240826   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WNK3 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	268	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	438	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase 2 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase 2 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	324	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Wee1-like protein kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Human)	BDBM50240826 (AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...) Show SMILES Show InChI	GoogleScholar	UniChem		601	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair