BDBM50241379 (enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1,3-dihydro-imidazol-2-one::4-Methyl-5-(4-methylsulfanyl-benzoyl)-1,3-dihydro-imidazol-2-one::4-Methyl-5-(4-methylsulfanyl-benzoyl)-1,3-dihydro-imidazol-2-one (Enoximone)::4-Methyl-5-(4-methylsulfanyl-benzoyl)-1,3-dihydro-imidazol-2-one(Enoximone)::4-Methyl-5-(4-methylsulfanyl-benzoyl)-1,3-dihydro-imidazol-2-one(fenoximone, MDL-17043)::5-methyl-4-(4-(methylthio)benzoyl)-1H-imidazol-2(3H)-one::CHEMBL249856::FENOXIMONE::MDL-17043

SMILES CSc1ccc(cc1)C(=O)c1[nH]c(=O)[nH]c1C

InChI Key InChIKey=ZJKNESGOIKRXQY-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50241379   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  5.20E+5nMAssay Description:Inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of canine heart Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of canine kidney Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of cAMP PDE III enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of guinea pig ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of canine cardiac cAMP phosphodiesterase (cAMP-PDE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of fraction III of guinea pig phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50241379((enoximone)4-Methyl-5-(4-methylsulfanyl-benzoyl)-1...)
Affinity DataIC50:  3.80E+3nMAssay Description:Binding affinity against sigma receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed