BDBM50241875 CHEMBL4091527

SMILES O=C(Nc1ccc(CN2CCOCC2)cc1)\C=C\c1cnccc1-c1cn[nH]c1

InChI Key InChIKey=CUSUZSREAOLZQQ-ZZXKWVIFSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50241875   

TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241875(CHEMBL4091527)
Affinity DataEC50:  21nMAssay Description:Inhibition of CDK8 in human SW480 cells assessed as reduction in IFN-gamma induced STAT1 phosphorylation at Ser727 residues preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241875(CHEMBL4091527)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241875(CHEMBL4091527)
Affinity DataIC50:  100nMAssay Description:Inhibition of kinase tracer 236 binding to GST-tagged CDK19/CycC (unknown origin) after 60 min by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed