BDBM50244219 CHEMBL4081453

SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@@H]2NC(=O)c1cccc(OC)c1)C(O)=O

InChI Key InChIKey=UXNRHIJPZNNDDJ-VZAVHYRXSA-N

Data  3 KI  5 IC50  10 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50244219   

TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataKi:  0.927nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2/3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataKi:  106nMAssay Description:Displacement of [3H]-LY459477 from mGlu2/3 receptor in Sprague-Dawley rat forebrain primary cortical membranes after 90 mins by liquid scintillation ...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataKi:  412nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu1 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: >1.25E+4nMAssay Description:Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  48nMAssay Description:Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  1.18E+4nMAssay Description:Agonist activity at recombinant human mGlu4 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at recombinant human mGlu5 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at human mGlu3 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  277nMAssay Description:Agonist activity at recombinant human mGlu2 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  1.95E+3nMAssay Description:Agonist activity at human mGlu6 receptor expressed in hamster AV12 cells co-expressing rat EAAT1 assessed as inhibition of forskolin-stimulated cAMP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu5 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50:  12nMAssay Description:Agonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at recombinant human mGlu4 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed