BDBM50244236 CHEMBL500315::trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentyloxy)-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide

SMILES Cn1c(nc2cc(OC3CCCC3)ccc12)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C

InChI Key InChIKey=JODMSXNYADHQBE-RQNOJGIXSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244236   

TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(CHEMBL500315 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  9nMAssay Description:Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(CHEMBL500315 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(CHEMBL500315 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity against human GIPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-glucagon(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244236(CHEMBL500315 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  5.00E+3nMAssay Description:Binding affinity against human GLP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed