BDBM50244296 (-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]methyl}-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol::CHEMBL472168::trans-(+)-7-((4-o-tolylpiperidin-1-yl)methyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol

SMILES Cc1ccccc1C1CCN(C[C@@H]2CCc3cccnc3[C@@H](O)C2)CC1

InChI Key InChIKey=RWZHKEZRFILBTQ-GCJKJVERSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50244296   

TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244296((-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]m...)
Affinity DataKi:  280nMAssay Description:Displacement of [125I][Tyr14]nociceptin from human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244296((-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]m...)
Affinity DataIC50: >1.00E+4nMAssay Description:Agonist activity at human ORL1 expressed in CHO cells by GTPgammaS binding assay relative to nociceptinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244296((-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]m...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244296((-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]m...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [35S]MK499 from human ERG K+ channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50244296((-)-(7R,9S)-7-{[4-(2-Methylphenyl)piperidin-1-yl]m...)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human ORL1 expressed in CHO cells assessed as effect on nociceptin-induced GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed