BDBM50246060 CHEMBL472212::CHEMBL541649::D3RKN_6::N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide::N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide::PF-431396

SMILES: CN(c1ccccc1CNc2c(cnc(n2)Nc3ccc4c(c3)CC(=O)N4)C(F)(F)F)S(=O)(=O)C

InChI Key: InChIKey=POJZIZBONPAWIV-UHFFFAOYSA-N

Data: 11 IC50  4 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50246060   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a
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Bromodomain-containing protein 4 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	445	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein-tyrosine kinase 2-beta (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Human)	BDBM50246060 (CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		8.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair