BDBM50246253 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine::AZD-5438::CHEMBL488436

SMILES: CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)S(C)(=O)=O)n1

InChI Key: InChIKey=WJRRGYBTGDJBFX-UHFFFAOYSA-N

Data: 14 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50246253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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G1/S-specific cyclin-D3 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-T1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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G2/mitotic-specific cyclin-B1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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G1/S-specific cyclin-E1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+6	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 9 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 6 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM50246253 (AZD-5438 | 4-(1-isopropyl-2-methyl-1H-imidazol-5-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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