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BDBM50246642 4,4-Difluoro-1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzyl-carbamoyl)-Lproline-N,N-dimethylamide::CHEMBL473917

SMILES: CN(C)C(=O)[C@@H]1CC(CN1C(=O)NCc1ccc(cc1C)C(=O)N1CCCCc2ccccc12)C(F)F

InChI Key: InChIKey=XZZQZDVCXFTLBM-GITCGBDTSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50246642   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vasopressin V2 receptor (V2)


(Homo sapiens (Human))
BDBM50246642
PNG
(4,4-Difluoro-1-(2-methyl-4-(2,3,4,5-tetrahydro-1-b...)
Show SMILES CN(C)C(=O)[C@@H]1CC(CN1C(=O)NCc1ccc(cc1C)C(=O)N1CCCCc2ccccc12)C(F)F
Show InChI InChI=1S/C28H34F2N4O3/c1-18-14-20(26(35)33-13-7-6-9-19-8-4-5-10-23(19)33)11-12-21(18)16-31-28(37)34-17-22(25(29)30)15-24(34)27(36)32(2)3/h4-5,8,10-12,14,22,24-25H,6-7,9,13,15-17H2,1-3H3,(H,31,37)/t22?,24-/m0/s1
UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Vantia Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as increase in intracellular cAMP level by CRE-luciferase report...


J Med Chem 51: 8124-34 (2008)


Article DOI: 10.1021/jm8008162
BindingDB Entry DOI: 10.7270/Q28W3D6V
More data for this
Ligand-Target Pair