BDBM50246967 CHEMBL4080228::US10570121, Example 81

SMILES: CC1=CC(=C(C(=O)N1)CN2CCc3c(cc(c(c3C2=O)Cl)[C@@H](C4COC4)OC)Cl)OC

InChI Key: InChIKey=RXCVUHMIWHRLDF-UHFFFAOYSA-N

Data: 4 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50246967   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C8 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Histone-lysine N-methyltransferase EZH2 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Histone-lysine N-methyltransferase EZH2 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histone-lysine N-methyltransferase EZH2 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histone-lysine N-methyltransferase EZH2 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Histone-lysine N-methyltransferase EZH1 (Human)	BDBM50246967 (CHEMBL4080228 | US10570121, Example 81) Show SMILES Show InChI	GoogleScholar	UniChem		70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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