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BDBM50247833 (3S,4R)-6-Chloro-2-[3-hydroxy-2,2-dimethyl-6-(piperidine-1-sulfonyl)-chroman-4-yl]-benzo[d] isoxazol-3-one::CHEMBL523312

InChI string: InChI=1S/C23H25ClN2O6S/c1-23(2)21(27)20(26-22(28)16-8-6-14(24)12-19(16)32-26)17-13-15(7-9-18(17)31-23)33(29,30)25-10-4-3-5-11-25/h6-9,12-13,20-21,27H,3-5,10-11H2,1-2H3/t20-,21+/m1/s1

SMILES: CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2cc(Cl)ccc2c1=O)S(=O)(=O)N1CCCCC1

InChI Key: InChIKey=FZWMAJYKWJFEHI-RTWAWAEBSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50247833   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247833
PNG
((3S,4R)-6-Chloro-2-[3-hydroxy-2,2-dimethyl-6-(pipe...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2cc(Cl)ccc2c1=O)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C23H25ClN2O6S/c1-23(2)21(27)20(26-22(28)16-8-6-14(24)12-19(16)32-26)17-13-15(7-9-18(17)31-23)33(29,30)25-10-4-3-5-11-25/h6-9,12-13,20-21,27H,3-5,10-11H2,1-2H3/t20-,21+/m1/s1
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Similars

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Article
PubMed
n/an/an/an/a 1.08E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair