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BDBM50247861 (3S,4R)-4-(5-Chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile::CHEMBL491472

InChI string: InChI=1S/C20H15ClN2O4/c1-20(2)17(24)16(14-7-10(9-22)3-6-15(14)27-20)23-18(25)12-5-4-11(21)8-13(12)19(23)26/h3-8,16-17,24H,1-2H3/t16-,17+/m1/s1

SMILES: CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N1C(=O)c2ccc(Cl)cc2C1=O)C#N

InChI Key: InChIKey=PXYGSKWAABMPHW-SJORKVTESA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50247861   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247861
PNG
((3S,4R)-4-(5-Chloro-1,3-dioxo-1,3-dihydro-isoindol...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N1C(=O)c2ccc(Cl)cc2C1=O)C#N
Show InChI InChI=1S/C20H15ClN2O4/c1-20(2)17(24)16(14-7-10(9-22)3-6-15(14)27-20)23-18(25)12-5-4-11(21)8-13(12)19(23)26/h3-8,16-17,24H,1-2H3/t16-,17+/m1/s1
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Article
PubMed
n/an/an/an/a 3.16E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Bioorg Med Chem 17: 855-66 (2009)

More data for this
Ligand-Target Pair