BindingDB logo
myBDB logout

BDBM50248022 5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazol-2-yl)-6-(piperidin-1-yl)nicotinamide::CHEMBL455445

SMILES: Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2cnc(N3CCCCC3)c(Cl)c2)n1

InChI Key: InChIKey=CGHUGQMSLZRHQE-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50248022   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50248022
PNG
(5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2cnc(N3CCCCC3)c(Cl)c2)n1
Show InChI InChI=1S/C21H17ClF4N4OS/c22-15-9-12(10-27-18(15)30-7-2-1-3-8-30)19(31)29-20-28-16(11-32-20)13-5-4-6-14(17(13)23)21(24,25)26/h4-6,9-11H,1-3,7-8H2,(H,28,29,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Bioorg Med Chem Lett 19: 1428-30 (2009)

More data for this
Ligand-Target Pair